- Caronositol (DCI) 150 mg / Myo-Inositol (MI) 550 mg is used for fertility treatment in women suffering from Polycystic Ovary Syndrome (PCOS).
- Improvement of functional deficiencies associated with PCOS were observed when DCI 150 mg was combined with MI 550 mg.1
- Increase in ovulation
- Reduction in hyperandrogenism
- Reduction of oxidative stress in follicular fluid
EFFICACY OF CARONOSITOL AND MYO-INOSITOL IN FERTILITY TREATMENT
- Myo-inositol (MI) and D-chiro-inositol (DCI) act like insulin mediators
- Therefore, both these molecules are involved in increasing insulin sensitivity of different tissues to improve metabolic and ovulatory functions2.
- Myo-inositol (MI)
- MI supplements have been observed to improve metabolic profile and hyperandrogenism in women suffering from PCOS.
In addition to increasing the clinical pregnancy rate in women undergoing ICSI.1
- MI exerts its beneficial effects mainly at the ovary level, where it is highly concentrated, by directly acting on several ovarian functions.2
- D-chiro-inositol (DCI)
- DCI restores normal insulin sensitivity in the insulin target tissues, thereby reducing the circulating insulin and androgens, and inducing an enhancement in ovulation frequency.
- The existence of tissue specific rations of these inositols in certain organs has resulted in studies that show better outcomes with the combination of MI:DCI vs the administration of each alone in the treatment for PCOS.2
WHAT IS POLYCYSTIC OVARY SYNDROME (PCOS)?
- PCOS affects 8%–13 % of women of reproductive age, and it is the most common cause of infertility in this group.3,4
- PCOS is a condition that affects a woman’s hormone levels.
- Women with PCOS produce higher-than-normal amounts of male hormones. This hormone imbalance causes them to skip menstrual periods and makes it harder for them to get pregnant.
- PCOS also causes hair growth on the face and body, and baldness. And it can contribute to long-term health problems like diabetes and heart disease.5
- PCOS is a “syndrome,” or group of symptoms that affects the ovaries and ovulation.5
- Cysts in ovaries
- High level of male hormone
- Irregular or skipped periods
CAUSES OF PCOS
- Currently, there is no known cause of PCOS
- However, there are associations with excess insulin, low-grade inflammation, and genetics. PCOS is thought to have a genetic component. People who have a mother or sister with PCOS are more likely to develop PCOS than someone whose relatives do not have the condition. This family link is the main risk factor.6
- Sugar is the body’s primary source of energy, and it is regulated in the body by insulin, which is secreted by the pancreas. A person with insulin resistance is unable to use insulin efficiently; up to 70% of women with PCOS have insulin resistance. This causes the pancreas to go into overdrive secreting additional insulin to meet the body’s glucose needs.5,6
- Excess insulin is thought to affect a woman’s ability to ovulate because of its effect on androgen production. Research has shown that women with PCOS have low-grade inflammation that stimulates polycystic ovaries to produce androgens.5,
- Insulin resistance is significantly exacerbated by obesity, and it is the key factor in lack of or reduced ovulation and increased male hormones.
- Other studies postulate that the increased androgen levels in PCOS suffering women might be linked to a decreased Myo-inositol (MI) /
D-chiro-inositol (DCI) ratio
- Inositols form part of the crucial messengers in insulin transduction.
- Given the high rate of obesity in women with PCOS, efforts to achieve weight reduction are an important part of treatment of the disorder. When effective, often as part of an organized program of lifestyle modification together with exercise and diet, weight loss has been shown to reduce increased male hormones, increase ovulation and rates of conception. Weight loss can also improve cholesterol levels, lower insulin, and reduce heart disease and diabetes risks.5,7
- Insulin-sensitizing compounds and weight loss have been proposed as treatment to solve the overproduction of insulin in women suffering from PCOS.3,8
- However, commonly used insulin-sensitizing drugs can induce gastrointestinal side effects possibly resulting in reduced patient compliance.
- There are a number of other effective fertility treatments available, eg. In Vitro Fertilization (IVF), clomiphene, hormonal treatments or injectable fertility drugs.8
- Most of these treatments are aimed at stimulating ovulation in women with PCOS who are struggling with fertility.
HOW TO TAKE SALOME™ FERTILITY (Caronositol 150 mg DCI/ 550 mg MI)
THE RECOMMENDED FERTILITY DOSAGE
- TAKE 1 CAPSULE TWICE DAILY before meals
- If you forget to take a SALOME™ FERTILITY capsule, do not take a double dose to make up for a forgotten capsule
Complementary Medicine: Health Supplement D 34.13
This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use